@article { author = {GH, Amin , and A, Haeri Rohani , and S, Nasri , and S, Oryan , and H, Yahyavi ,}, title = {-}, journal = {Iranian International Journal of Science(Not Publish)}, volume = {5}, number = {0}, pages = {-}, year = {2004}, publisher = {}, issn = {}, eissn = {}, doi = {}, abstract = {Usually, the side effects of synthetic drugs appear after a long time of their usage. For that reason, these years, diseases treatment by herbal drugs is very interested. In this study, regarding to the mentioned purposes, we evaluate the effects of Vitex agnus castus L. (Vit.) fruit extract on the activity of Pituitary- Gonadal axis in Balb/C male mice. LD50 of the extract was obtained 1650 mg/kg. Regarding to the LD50 of the extract, the following doses (65, 165, 265, 365, 465 mg/kg) were injected intraperitoneally for 30 days in 5 groups of animals. After the last injection, we collected the blood samples and measured FSH, LH and testosterone by Radio Immuno Assay (RIA) technique. Vitex extract decreased the FSH, LH and testosterone levels comparing to the control and sham groups. The optimum dose was obtained 365 mg/kg. These results suggest that Vit. fruit extract has an anti-androgenic effect and probably acts through the Hypothalamic-Pituitary- Gonadal (HPG) axis}, keywords = {FSH,LD50,LH,Testosterone,Vitex agnus castus}, title_fa = {-}, abstract_fa = {}, keywords_fa = {}, url = {https://iijs.ut.ac.ir/article_30800.html}, eprint = {https://iijs.ut.ac.ir/article_30800_3cfa410aeb50a09a6d0eaeeb1e2177ec.pdf} }