@article { author = {G?mez-Jeria, Juan S. and Soto-Morales, Francisco and Larenas-Gutierrez, Gipsy}, title = {-}, journal = {Iranian International Journal of Science(Not Publish)}, volume = {4}, number = {0}, pages = {-}, year = {2003}, publisher = {}, issn = {}, eissn = {}, doi = {}, abstract = {We present here the results of a formal structure-property relationship study carried out for - and -mediated inhibition of adenylyl cyclase (ADC) by a group of classical cannabinoid derivatives. The wave function was calculated with Zerner’s ZINDO/1 method. Several reactivity indices were calculated from the wave function for a molecular skeleton common to all the molecules. Multiple regression analysis was employed to find the best equation for each case. We found that: (1). the variation of the the cannabinoid-mediated inhibition of ADC is related to the variation of a definite set of molecular reactivity indices, (2). the internal molecular orbitals are extremely important in regulating the cannabinoid-receptor interaction, and (3). the mechanism for the cannabinoid-mediated inhibition of ADC is different for each receptor, involving electrostatic interactions, electron transfer and geometrical substituent effects.}, keywords = {adenylyl cyclase inhibition,Cannabinoids,CB1 receptor,CB2 receptor,Structure-activity relationships,ZINDO/1}, title_fa = {-}, abstract_fa = {}, keywords_fa = {}, url = {https://iijs.ut.ac.ir/article_30961.html}, eprint = {https://iijs.ut.ac.ir/article_30961_18938be361fe2eaf714f73ce597803cf.pdf} }